Heavy-tailed distributions and hierarchical cell assemblies
In earlier work, we meticulously documented the distribution of synaptic weights and the gain (or activation function) in many different brain areas. We found a remarkable consistency of heavy-tailed,...
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Soft coded Synapses
A new preprint by Filipovicetal2009* shows that striatal projection neurons (MSNs) receive different amounts of input, dependent on whether they are D2-modulated, and part of the indirect pathway, or...
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Why a large cortex?
If we compare a small mouse cortex with a large human cortex, the connectivity per neuron is approximately the same (10^4/neuron SchuezPalm1989). So why did humans add so many neurons, and why did the...
View ArticleCocaine Dependency and restricted learning
Substantial work (NasifFJetal2005a, NasifFJetal2005b , DongYetal2005 , HuXT2004, Marinellietal2006) has shown that repeated cocaine administration changes the intrinsic excitability of prefrontal...
View ArticleTwo parts of the brain
Here is an image from the 10th art of neuroscience contest. It is striking in that it gives a view of the brain, where there are two major parts: the cerebrum and the cerebellum. Of course there are a...
View ArticleFunctional Principles of Neural Plasticity
10.13140/RG.2.2.20967.37282 It is really difficult to conceptualize things in a novel way – when one has been conditioned for decades to believe in the synaptic plasticity theory of memory.I offer a...
View ArticleLearning in the Brain: Difference learning vs. Associative learning
The feedforward/feedback learning and interaction in the visual system has been analysed as a case of “predictive coding” , the “free energy principle” or “Bayesian perception”. The general principle...
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